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Overview Table of Safety Studies and Findings

The rebiana safety evaluation program included metabolism and pharmacokinetic studies, general and multi-generational safety studies, intake studies and human studies. Cargill sponsored the studies to affirm earlier safety findings for purified steviol glycosides, and to confirm that rebiana is broken down by the body in the same way as stevioside, which has been studied extensively. Rebaudioside A - the main component of rebiana - is nearly identical in chemical structure to stevioside.

Study	Top-line Findings	Implications
Metabolism and pharmacokinetic studies	Metabolism of rebaudioside A is similar to that of stevioside	Safety data from stevioside studies can be applied to rebiana The safety of rebiana is supported by a large database of scientific research
General safety	No negative effects on general health associated with doses equivalent to a 150-lb person drinking more than 2,000 8-ounce servings of a rebiana-sweetened beverage No treatment-related effects on any organ, including kidneys and male reproductive organs	Supports safety of high-purity steviol glycoside ingredients, including rebiana Refutes outdated studies suggesting adverse effects of stevia or stevioside on male reproductive organs (1985, 1999) or on kidney function (1988, 1994, 1997) Rebiana does not affect general health or organ function
Multi-generational/ reproductive toxicology	Daily consumption equivalent to a 150-lb person drinking nearly 1,000 8-oz servings of a rebiana-sweetened beverage had no negative effects on general health, reproduction, growth or development of adults or their offspring	Refutes studies (1968, 1985, 1998, 1999) suggesting potential adverse effects on male or female fertility, or health of offspring Rebiana does not affect reproductive health or health of offspring
Chronic blood pressure study	Daily consumption of 1,000 mg rebiana - equivalent to drinking more than eight 8-oz servings of a rebiana-sweetened beverage every day - for 4 weeks had no significant blood pressure effects in healthy subjects with normal or low-normal blood pressure	Addresses questions raised by two Taiwanese studies (2000 and 2003) suggesting that stevioside (purity unknown) lowered blood pressure in people with essential hypertension Rebiana does not affect blood pressure
Chronic blood sugar study	Daily consumption of 1,000 mg of rebiana - equivalent to drinking more than eight 8-ounce servings of a rebiana-sweetened beverage every day - for 16 weeks did not affect blood sugar control and was well-tolerated in people with type 2 diabetes	Addresses questions raised by a single-dose study (2004) suggesting that stevioside reduced levels of blood sugar after meals in people with type 2 diabetes Rebiana does not affect blood sugar control in people with type 2 diabetes

In safety studies, daily consumption of rebiana equivalent to a 150-lb person drinking between 1,000 and 2,000 8-ounce servings of rebiana-sweetened beverage had no negative effects on the general health, reproduction, growth or development of adults or their offspring.
In clinical studies, daily consumption of 1,000 mg rebiana - equivalent to consuming 29 packets of sweetener or drinking approximately eight 8-ounce servings of a rebiana-sweetened beverage every day for 4 or 16 weeks - had no effect on blood pressure in healthy subjects with normal or low-normal blood pressure; or on blood sugar control in subjects with type 2 diabetes.

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Overview Table of Safety Studies and Findings

Study

Top-line Findings

Implications